Genomic Testing for Relapsed and Refractory Lymphoid Cancers: Understanding Patient Values
نویسندگان
چکیده
منابع مشابه
Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma
Proteasome inhibition forms the cornerstone of antimyeloma therapy. The first-in-class proteasome inhibitor, bortezomib, either alone or in combination with other chemotherapeutic agents, induces high overall response rates and response qualities in patients with clinically and molecularly defined high-risk disease. However, resistance to bortezomib and neurotoxicity associated with the treatme...
متن کاملRelapsed and refractory lymphoid neoplasms and multiple myeloma with a focus on carfilzomib
Proteasomal inhibition revolutionized myeloma therapies in this decade of novel agents. The only US Food and Drug Administration approved proteasome inhibitor so far, bortezomib effectively targets the constitutive proteasome subunit β5 of the 26S proteasome. Bortezomib induces high and quality response rates that are durable. However, myeloma cells acquire resistance to bortezomib through vari...
متن کاملRelapsed and RefRactoRy Multiple MyeloMa
• Objective: To review the management considerations in patients with relapsed and refractory multiple
متن کاملExperience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies.
We explored the safety and efficacy of rituximab plus alemtuzumab in patients with relapsed or refractory lymphoid malignancies. Forty-eight patients were treated and were assessable for response (32 with chronic lymphocytic leukemia [CLL], 9 with CLL/prolymphocytic leukemia [PLL], 1 with PLL, 4 with mantle cell leukemia/lymphoma, 2 with Richter transformation). The overall response rate was 52...
متن کاملIdentification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing
Novel agents have increased survival of multiple myeloma (MM) patients, however high-risk and relapsed/refractory patients remain challenging to treat and their outcome is poor. To identify novel therapies and aid treatment selection for MM, we assessed the ex vivo sensitivity of 50 MM patient samples to 308 approved and investigational drugs. With the results we i) classified patients based on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Patient - Patient-Centered Outcomes Research
سال: 2020
ISSN: 1178-1653,1178-1661
DOI: 10.1007/s40271-020-00448-1